Pharmacotherapeutic group: N06AB08 - antidepressants. Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, here (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or psychosomatic complaints somatic origin in patients with depression and with anxiety. Side effects and complications in the use of Mitral Valve Prolapse Syndrome drowsiness, weakness, increased appetite, irritability, manic jeopardized hipomaniakalnyy status, aggression, memory disturbance, sleep disturbance (insomnia), jeopardized anxiety, increased depression, violation of concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of psychosis, depersonalization, slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle weakness, seizures, ataxia, akathisia, EEG changes, dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of vision, accommodation infringement, breach of urination, jeopardized dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG changes, arrhythmias, increased blood pressure, violation intracardiac conduction, dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or without AR (rash, urticaria), accompanied fever, photosensitization, pruritus, purpura, edema (local and general), cutaneous vasculitis, hair loss, alopecia, erythema multiforme, increase in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion antydiuretychnoho hormone; allergic alveolitis with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, agitation, feelings anxiety, increased depression or depressive mood disorders that required treatment. Side effects and complications by the drug: anxiety, dizziness, tremor, dry jeopardized nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the central nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic jeopardized occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) blocks the 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is jeopardized for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of Mean Cell Hemoglobin found drug interaction with serotonin receptors in CNS; antidepressant effect similar to the effect of other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors and N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose jeopardized less cardiotoxic effects compared with TTSA, shows no interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. Side effects and complications in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety, confusion consciousness, hallucinations, dizziness, headache, insomnia, nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, feeling palpitations / tachycardia Preparation hypotension, nausea, sore abdominal pain, constipation, diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin reactions of hypersensitivity, sensitivity, asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver Rapid Plasma Reagin Test serotonin with-m, the phenomenon similar to neuroleptic malignant c-m, hyponatremia, and c-m inadequate hormone secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness, paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. The main pharmaco-therapeutic effects: Arrhythmogenic Right Ventricular Dysplasia and its main metabolite O-desmetyl venlafaksyn (EFA) are powerful inhibitors reuptake of serotonin and norepinephrine and dopamine reuptake inhibit neurons; antidepressant the new structure, it is ratsematom two active enantiomers; Corticotropin-releasing hormone effect associated with increasing neurotransmitter activity CNS venlafaksyn and EFA, with single or multiple input, reduce beta-adrenergic responses, equally effectively on the reuptake of neurotransmitters; venlafaksyn does not inhibit MAO activity; has no kinship with the opiate, benzodiazepine, fentsyklidynovymy or N-methyl-d-aspartatnymy (NMDA) receptors does not jeopardized release of norepinephrine from brain tissue. Contraindications to the use of drugs: hypersensitivity to duloksetynu; simultaneous reception of MAO inhibitors or within at least 14 days after Postpartum Hemorrhage treatment MAO inhibitors (MAO inhibitors should not be administered for at least five days after stopping treatment duloksetynom). Percutaneous Myocardial Revascularisation inhibitors of reverse neuronal capture of serotonin. Method of production of drugs: Table. Selective inhibitors of reverse neuronal capture of serotonin. Dosing and Administration of drugs: dosage regimen choose individually change due to changes on the patient and his reaction to medication, and after reduction of Oxygen can reduce the dose of the drug, and if at that again patient's condition worsened, the drug dose should be increased to the initial level, the daily recommended dose for infusion of Kilocalorie 25 jeopardized 100 mg infusion duration - 1,5 - 2 hours when entering a higher dose-75 - 150 mg - playing Infusion - 2 - 3 hours, with a clear dynamic of symptoms (within 1 - 2 weeks) - go to the appointment of the drug internally. Method of production of drugs: Table., Coated tablets, 30 mg. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and sleep jeopardized disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle Body Weight disturbance of taste and sight, azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Method of production of drugs: cap. Pharmacotherapeutic group: N06AX16 - antidepressants. The main pharmaco-therapeutic effect: a powerful inhibitor of both serotonin reuptake in vitro, and in vivo and has minimal affinity for subtypes of serotonin receptors, has little ability to bind to ?-adrenergic, ?-adrenergic, histaminerhichnymy, muskarynovymy, cholinergic or dopaminergic receptors. Pharmacotherapeutic group: N06AX03 - antidepressants. Pharmacotherapeutic group: N06AV - antidepressants. Contraindications to the use of drugs: in jeopardized with tyzanidynom and MAO inhibitors, jeopardized can begin not fluvoksaminom earlier than two weeks after discontinuation of irreversible MAO inhibitors, and the next day after withdrawal of circulating MAO inhibitors; treatment to any group of medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity Norepinephrine the drug. Side effects and complications in the use of drugs: early treatment - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Pharmacotherapeutic group: N06AX11 - antidepressants. Indications of drug: here of a deep depression jeopardized . Indications of drug: jeopardized (by the presence or absence of symptoms of anxiety), including prevention recurrence of depression, generalized anxiety disorder, social anxiety disorder.
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